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Page 1
ACE2 negatively regulates the Warburg effect and suppresses hepatocellular carcinoma progression via reducing ROS-HIF1alpha activity.
Dong F, Li H, Liu L, Yao LL, Wang J, Xiang D, Ma J, Zhang G, Zhang S, Li J, Jiang SH, Hu X, Chen J, Bao Z. Dong F, et al. Int J Biol Sci. 2023 May 11;19(8):2613-2629. doi: 10.7150/ijbs.81498. eCollection 2023. Int J Biol Sci. 2023. PMID: 37215979 Free PMC article.
Overexpression of ACE2 significantly retards tumor growth in patient-derived xenograft model. Collectively, our findings suggest that ACE2 is a negative glycolytic regulator, and targeting the ACE2/Ang-(1-7)/Mas receptor/ROS/HIF1alpha axis may be a promising …
Overexpression of ACE2 significantly retards tumor growth in patient-derived xenograft model. Collectively, our findings suggest that …
Vitamin C promotes ACE2 degradation and protects against SARS-CoV-2 infection.
Zuo Y, Zheng Z, Huang Y, He J, Zang L, Ren T, Cao X, Miao Y, Yuan Y, Liu Y, Ma F, Dai J, Tian S, Ding Q, Zheng H. Zuo Y, et al. EMBO Rep. 2023 Apr 5;24(4):e56374. doi: 10.15252/embr.202256374. Epub 2023 Mar 6. EMBO Rep. 2023. PMID: 36876523 Free PMC article.
ACE2 is a major receptor for cellular entry of SARS-CoV-2. Despite advances in targeting ACE2 to inhibit SARS-CoV-2 binding, strategies to flexibly and sufficiently reduce ACE2 levels for the prevention of SARS-CoV-2 infection have not been explored. ...Furth …
ACE2 is a major receptor for cellular entry of SARS-CoV-2. Despite advances in targeting ACE2 to inhibit SARS-CoV-2 binding, s …
The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice.
Bao L, Deng W, Huang B, Gao H, Liu J, Ren L, Wei Q, Yu P, Xu Y, Qi F, Qu Y, Li F, Lv Q, Wang W, Xue J, Gong S, Liu M, Wang G, Wang S, Song Z, Zhao L, Liu P, Zhao L, Ye F, Wang H, Zhou W, Zhu N, Zhen W, Yu H, Zhang X, Guo L, Chen L, Wang C, Wang Y, Wang X, Xiao Y, Sun Q, Liu H, Zhu F, Ma C, Yan L, Yang M, Han J, Xu W, Tan W, Peng X, Jin Q, Wu G, Qin C. Bao L, et al. Nature. 2020 Jul;583(7818):830-833. doi: 10.1038/s41586-020-2312-y. Epub 2020 May 7. Nature. 2020. PMID: 32380511
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which has become a public health emergency of international concern(1). Angiotensin-converting enzyme 2 (ACE2) is the cell-entry receptor for severe acute resp …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which has become a public …
Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Li M, Ren Y, Aw ZQ, Chen B, Yang Z, Lei Y, Cheng L, Liang Q, Hong J, Yang Y, Chen J, Wong YH, Wei J, Shan S, Zhang S, Ge J, Wang R, Dong JZ, Chen Y, Shi X, Zhang Q, Zhang Z, Chu JJH, Wang X, Zhang L. Li M, et al. Nat Commun. 2022 Dec 27;13(1):7957. doi: 10.1038/s41467-022-35642-2. Nat Commun. 2022. PMID: 36575191 Free PMC article.
Crystal structure analysis of one representative nanobody, 3-2A2-4, discovers a highly conserved epitope located between the cryptic and the outer face of the receptor binding domain (RBD), distinctive from the receptor ACE2 binding site. Cryo-EM and biochemical evaluation …
Crystal structure analysis of one representative nanobody, 3-2A2-4, discovers a highly conserved epitope located between the cryptic and the …
Heterogeneous expression of ACE2, TMPRSS2, and FURIN at single-cell resolution in advanced non-small cell lung cancer.
Liu Z, Gu X, Li Z, Shan S, Wu F, Ren T. Liu Z, et al. J Cancer Res Clin Oncol. 2023 Jul;149(7):3563-3573. doi: 10.1007/s00432-022-04253-1. Epub 2022 Aug 12. J Cancer Res Clin Oncol. 2023. PMID: 35960376 Free PMC article.
Among all cell types, ACE2, TMPRSS2 and FURIN were predominately expressed in cancer cells and alveolar cells, and lowly uncovered in other cells. ...Moreover, ACE2, TMPRSS2, and FURIN expressions were not higher in any cell type of smokers than non-smokers. ...
Among all cell types, ACE2, TMPRSS2 and FURIN were predominately expressed in cancer cells and alveolar cells, and lowly uncovered in …
ACE2 and FZD1 are prognosis markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of gallbladder.
Li J, Yang ZL, Ren X, Zou Q, Yuan Y, Liang L, Chen M, Chen S. Li J, et al. J Mol Histol. 2014 Feb;45(1):47-57. doi: 10.1007/s10735-013-9528-1. Epub 2013 Aug 7. J Mol Histol. 2014. PMID: 23921915

The average survival time in SC/ASC and AC patients with FZD1(-)ACE2(+) expression was significantly longer than that in patients with FZD1(+)ACE2(-) or FZD1(+)ACE2(+) (p < 0.01). ...In addition, FZD1 expression positively, but ACE2 expression negat

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The average survival time in SC/ASC and AC patients with FZD1(-)ACE2(+) expression was significantly longer than that in patients wit …
Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19.
Ren X, Wang S, Chen X, Wei X, Li G, Ren S, Zhang T, Zhang X, Lu Z, You Z, Wang Z, Song N, Qin C. Ren X, et al. Infect Drug Resist. 2020 Nov 4;13:3977-3990. doi: 10.2147/IDR.S270543. eCollection 2020. Infect Drug Resist. 2020. PMID: 33177848 Free PMC article.
Multiple sequence alignment of ACE2 in different species was used to explain animal susceptibility. ...Additional biological relevance was determined through Gene Set Enrichment Analysis (GSEA) using an ACE2-specific signature. RESULTS: Our results revealed that …
Multiple sequence alignment of ACE2 in different species was used to explain animal susceptibility. ...Additional biological relevanc …
A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75.
Huo J, Dijokaite-Guraliuc A, Liu C, Zhou D, Ginn HM, Das R, Supasa P, Selvaraj M, Nutalai R, Tuekprakhon A, Duyvesteyn HME, Mentzer AJ, Skelly D, Ritter TG, Amini A, Bibi S, Adele S, Johnson SA, Paterson NG, Williams MA, Hall DR, Plowright M, Newman TAH, Hornsby H, de Silva TI, Temperton N, Klenerman P, Barnes E, Dunachie SJ, Pollard AJ, Lambe T, Goulder P; OPTIC consortium; ISARIC4C consortium; Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR. Huo J, et al. Cell Rep. 2023 Jan 31;42(1):111903. doi: 10.1016/j.celrep.2022.111903. Epub 2022 Dec 14. Cell Rep. 2023. PMID: 36586406 Free PMC article.
Here, we perform an antigenic and biophysical characterization of BA.2.75, revealing an interesting balance between humoral evasion and ACE2 receptor affinity. ACE2 affinity for BA.2.75 is increased 9-fold compared with BA.2; there is also evidence of escape of BA.2 …
Here, we perform an antigenic and biophysical characterization of BA.2.75, revealing an interesting balance between humoral evasion and A …
Combined suppression of the intrarenal and circulating vasoconstrictor renin-ACE-ANG II axis and augmentation of the vasodilator ACE2-ANG 1-7-Mas axis attenuates the systemic hypertension in Ren-2 transgenic rats exposed to chronic hypoxia.
Červenka L, Bíbová J, Husková Z, Vaňourková Z, Kramer HJ, Herget J, Jíchová Š, Sadowski J, Hampl V. Červenka L, et al. Physiol Res. 2015;64(1):11-24. doi: 10.33549/physiolres.932842. Epub 2014 Sep 5. Physiol Res. 2015. PMID: 25194129 Free article.
The aim of the present study was to test the hypothesis that chronic hypoxia would aggravate hypertension in Ren-2 transgenic rats (TGR), a well-defined monogenetic model of hypertension with increased activity of endogenous renin-angiotensin system (RAS). ...Simultaneousl …
The aim of the present study was to test the hypothesis that chronic hypoxia would aggravate hypertension in Ren-2 transgenic rats (T …
155 results